Exploring the Diagnostic Dilemma of Indeterminate Pulmonary Nodules in Patients with Primary Sarcoma of Bone
Table 3
Development of indeterminant chest CT nodules in patients with primary sarcoma of the bone without evident metastatic disease on presentation.
Patients who developed indeterminant nodules on follow-up CT scans of the chest
Patients who did not develop indeterminant nodules on follow-upCT scans of the chest
value
N
58
59
Age (years)
49.6 (16–81)
47.7 (16–77)
0.591
Follow-up (months)
40.8 (2–192)
35.9 (1–128)
0.189
Gender
Male
34 (58.6%)
35 (59.3%)
0.939
Female
24 (41.4%)
24 (40.7%)
Smoking history
Never
38 (65.5%)
32 (54.2%)
0.450
+Smoking history
15 (25.9%)
21 (35.6%)
Unknown
5 (8.6%)
6 (10.2%)
Diagnosis
Osteosarcoma
14 (24.1%)
22 (37.3%)
0.123
Chondrosarcoma
23 (39.7%)
26 (44.1%)
Ewing sarcoma
5 (8.6%)
3 (5.1%)
Chordoma
4 (6.9%)
0 (0%)
Others
12 (20.7%)
8 (13.6%)
Grade
Low
3 (5.2%)
5 (8.5%)
0.479
High
55 (94.8%)
54 (91.5%)
Anatomic location
Upper extremity
11 (19.0%)
10 (16.9%)
0.619
Lower extremity
22 (37.9%)
26 (44.1%)
Spine/chest wall
5 (8.6%)
8 (13.6%)
Pelvis
20 (34.5%)
15 (25.4%)
Presence of indeterminant nodules on preoperative CT chest
Yes
25 (43.1%)
48 (81.4%)
<0.001
No
33 (56.9%)
11 (18.6%)
If present, size of largest nodule on preoperative CT chest
1–5 mm
20 (80.0%)
37 (77.1%)
0.253
6–9 mm
2 (8.0%)
9 (18.8%)
10+ mm
3 (12.0%)
2 (4.2%)
If present, number of nodules each patient had at the time of preoperative CT chest
1
11 (44.0%)
9 (18.8%)
0.059
2
8 (32.0%)
13 (27.1%)
3
5 (20.0%)
13 (27.1%)
4
0 (0%)
6 (12.5%)
5+
1 (4.0%)
7 (14.6%)
Progressed to metastatic disease
Yes
32 (55.2%)
17 (28.8%)
0.004
No
26 (44.8%)
42 (71.2%)
Time to metastatic disease (months)
20.0 (2–86)
10.3 (2–35)
0.033
value: comparison of patients presenting with indeterminant nodules who went on to develop metastatic disease vs. those who did not develop metastatic disease, performed with Chi-square and Mann–Whitney U tests.
