Adult Pleomorphic Rhabdomyosarcomas: Assessing Outcomes Associated with Radiotherapy and Chemotherapy Use in the National Cancer Database

Table 4

Factors associated with receipt of chemotherapy.

Receipt of chemotherapy	Univariate analysis		Multivariate analysis
	OR (95% CI)	value	OR (95% CI)	value
Age
<70 years	1		1
≥70 years	0.15 (0.08–0.28)	<0.001	0.17 (0.08–0.39)	<0.001
Gender
Male	1		—	—
Female	0.76 (0.45–1.28)	0.301	—	—
Race
Non-Hispanic White	1		—	—
Non-Hispanic Black	2.42 (0.92–6.33)	0.072	—	—
Hispanic	0.50 (0.17–1.46)	0.205	—	—
Other	1.30 (0.44–3.85)	0.635	—	—
Facility area
Metropolitan	1		—	—
Urban	1.05 (0.46–2.37)	0.915	—	—
Rural	0.17 (0.02–1.44)	0.105	—	—
Unknown	1.63 (0.35–7.45)	0.531	—	—
Facility location
East	1		1
South	0.70 (0.32–1.52)	0.367	0.88 (0.35–2.18)	0.775
Central	1.05 (0.47–2.34)	0.907	1.03 (0.41–2.59)	0.944
West	1.04 (0.46–2.33)	0.928	1.13 (0.45–2.86)	0.795
Unknown	5.75 (1.84–17.98)	0.003	3.65 (0.95–13.95)	0.059
Facility type
Non-academic	1		1
Academic	1.39 (0.81–2.41)	0.234	1.23 (0.65–2.34)	0.520
Insurance
Commercial	1		1
Medicare	0.29 (0.16–0.51)	<0.001	0.91 (0.42–1.96)	0.801
Medicaid	2.49 (0.76–8.10)	0.130	2.72 (0.72–10.24)	0.140
Uninsured	0.38 (0.03–4.34)	0.438	0.43 (0.03–5.48)	0.517
Other	0.26 (0.05–1.32)	0.103	0.33 (0.05–2.03)	0.233
Distance to treatment facility
≤40 miles	1		—	—
>40 miles	.	.	—	—
Zip code education level
≥21%	1		1
13%–20.9%	0.95 (0.41–2.22)	0.910	1.03 (0.37–2.82)	0.961
7%–12.9%	1.81 (0.82–3.98)	0.140	1.64 (0.65–4.17)	0.298
<7%	2.16 (0.96–4.84)	0.062	2.72 (1.02–7.25)	0.045
Zip code income level
<38,000	1		—	—
38,000–47,999	1.27 (0.54–2.96)	0.586	—	—
48,000–62,999	1.73 (0.79–3.82)	0.174	—	—
≥63,000	1.98 (0.90–4.36)	0.089	—	—
Charlson/Deyo score
0	1		—	—
1	0.72 (0.35–1.49)	0.374	—	—
2	0.45 (0.09–2.39)	0.350	—	—
3	.	.	—	—
Primary site
Extremity	1		—	—
Head and neck	4.27 (1.11–16.38)	0.034	—	—
Thorax	1.55 (0.65–3.73)	0.325	—	—
Abdomen/pelvis	1.00 (0.51–1.95)	0.995	—	—
Tumor size
<5 cm	1		—	—
5.1–10 cm	1.28 (0.64–2.55)	0.486	—	—
10.1–15 cm	2.30 (1.04–5.06)	0.039	—	—
>15 cm	1.10 (0.46–2.60)	0.831	—	—
Grade
II	1		—	—
III	0.65 (0.19–2.20)	0.493	—	—
Receipt of radiotherapy
No	1		—	—
Yes	1.35 (0.80–2.26)	0.257	—	—
Year of diagnosis
2004–2007	1		1
2008–2011	2.12 (1.11–4.04)	0.023	1.75 (0.81–3.77)	0.152
2012–2015	0.93 (0.49–1.74)	0.810	0.84 (0.40–1.73)	0.633