Research Article
Adult Pleomorphic Rhabdomyosarcomas: Assessing Outcomes Associated with Radiotherapy and Chemotherapy Use in the National Cancer Database
Table 3
Factors associated with overall survival in patients with localized disease.
| | Univariate analysis | Multivariate analysis | HR (95% CI) | value | HR (95% CI) | value |
| Receipt of radiation | No | 1 | | 1 | | Yes | 0.50 (0.34–0.74) | <0.001 | 0.48 (0.32–0.72) | <0.001 | Receipt of chemotherapy | No | 1 | | 1 | | Yes | 0.50 (0.33–0.75) | 0.001 | 0.65 (0.41–1.03) | 0.064 | Age | <70 years | 1 | | 1 | | ≥70 years | 2.50 (1.70–3.67) | <0.001 | 1.55 (0.83–2.90) | 0.171 | Gender | Male | 1 | | — | — | Female | 1.11 (0.75–1.64) | 0.594 | — | — | Race | Non-Hispanic White | 1 | | — | — | Non-Hispanic Black | 0.72 (0.36–1.43) | 0.345 | — | — | Hispanic | 0.43 (0.16–1.18) | 0.101 | — | — | Other | 0.75 (0.30–1.85) | 0.530 | — | — | Facility area | Metropolitan | 1 | | 1 | | Urban | 0.48 (0.22–1.04) | 0.062 | 0.48 (0.21–1.09) | 0.078 | Rural | 1.54 (0.49–4.88) | 0.461 | 1.81 (0.53–6.20) | 0.344 | Unknown | 1.70 (0.62–4.63) | 0.302 | 2.73 (0.93–8.00) | 0.066 | Facility location | East | 1 | | 1 | | South | 1.16 (0.67–2.02) | 0.601 | 1.09 (0.60–1.98) | 0.781 | Central | 1.27 (0.71–2.29) | 0.420 | 1.52 (0.77–2.99) | 0.228 | West | 1.01 (0.54–1.88) | 0.971 | 1.14 (0.59–2.18) | 0.701 | Unknown | 0.37 (0.14–1.00) | 0.049 | 0.85 (0.28–2.56) | 0.777 | Facility type | Non-academic | 1 | | 1 | | Academic | 0.95 (0.64–1.41) | 0.803 | 0.93 (0.61–1.43) | 0.753 | Unknown | 0.32 (0.13–0.82) | 0.017 | . | . | Insurance | Commercial | 1 | | 1 | | Medicare | 2.34 (1.55–3.53) | <0.001 | 1.38 (0.72–2.62) | 0.332 | Medicaid | 1.21 (0.51–2.88) | 0.660 | 0.79 (0.31–2.01) | 0.626 | Uninsured | . | . | . | . | Other | 0.71 (0.10–5.18) | 0.736 | 0.82 (0.11–6.26) | 0.845 | Distance to treatment facility | ≤40 miles | 1 | | — | — | >40 miles | 1.04 (0.68–1.59) | 0.859 | — | — | Zip code education level | ≥21% | 1 | | — | — | 13%–20.9% | 1.97 (1.04–3.71) | 0.037 | — | — | 7%–12.9% | 1.28 (0.68–2.43) | 0.445 | — | — | <7% | 1.51 (0.80–2.83) | 0.202 | — | — | Zip code income level | <38,000 | 1 | | — | — | 38,000–47,999 | 0.91 (0.50–1.65) | 0.747 | — | — | 48,000–62,999 | 0.78 (0.44–1.39) | 0.402 | — | — | ≥63,000 | 0.88 (0.50–1.53) | 0.646 | — | — | Charlson/Deyo score | 0 | 1 | | 1 | | 1 | 1.90 (1.14–3.15) | 0.013 | 1.71 (0.98–2.99) | 0.059 | 2 | 1.63 (0.51–5.19) | 0.406 | 1.35 (0.41–4.48) | 0.624 | 3 | 2.45 (0.77–7.79) | 0.130 | 0.95 (0.27–3.33) | 0.939 | Primary site | Head and neck | 1 | | — | — | Upper extremity | 1.25 (0.41–3.81) | 0.689 | — | — | Lower extremity | 1.80 (0.65–4.98) | 0.259 | — | — | Thorax | 2.07 (0.67–6.41) | 0.209 | — | — | Abdomen/pelvis | 2.41 (0.83–6.97) | 0.105 | — | — | Other/NOS | . | . | . | . | Tumor size | <5 cm | 1 | | 1 | | 5.1–10 cm | 1.50 (0.85–2.64) | 0.162 | 1.40 (0.77–2.57) | 0.271 | 10.1–15 cm | 1.83 (0.97–3.45) | 0.063 | 1.70 (0.84–3.45) | 0.141 | >15 cm | 3.62 (1.94–6.74) | <0.001 | 3.23 (1.59–6.53) | 0.001 | Grade | II | 1 | | 1 | | III | 2.93 (0.72–11.90) | 0.132 | 2.09 (0.49–8.87) | 0.320 | Year of diagnosis | 2004–2007 | 1 | | — | — | 2008–2011 | 0.70 (0.45–1.10) | 0.121 | — | — | 2012–2015 | 0.71 (0.42–1.22) | 0.215 | — | — |
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