| Author | Year | No. of patients | No. of fractures | STS location | Significant variables identified | Reference |
| Brant et al. | 1990 | 52 | 4 | Long bone | Periosteal stripping, age, female gender; descriptive only | [29] | Lin et al. | 1998 | 205 | 5 | Thigh | Univariate: compartment, periosteal stripping, female gender, chemotherapy, age, RT type Multivariate: periosteal stripping Secondary multivariate model: female gender, chemotherapy | [11] | Helmstedter et al. | 2001 | 285 (thigh subset: 163) | 20 (thigh subset: 12) | Extremity | Logistic regression (thigh subset): periosteal stripping, compartment, marginal/intralesional resection | [30] | Holt et al. | 2006 | 354 (thigh subset: 239) | 27 (thigh subset: 24) | Lower extremity | Univariate: periosteal stripping, compartment, age, radiation dose Multivariate: age, radiation dose Univariate (thigh subset): female gender, age Multivariate (thigh subset): female gender, age, radiation dose, radiation timing | [9] | Livi et al. | 2005 | 214 | 7 | Extremity | None | [31] | Dickie et al. | 2009 | 691 | 31a | Lower extremity | Radiation dose (mean, maximum, proportional volume irradiated) | [32] | Gortzak et al. | 2010 | 101 | 22 | Thigh | Univariate: age, tumor size, periosteal stripping, compartment Multivariate: age, tumor size, gender | [12] | Kim et al. | 2010 | 1045 | 39 | Thigh | Diaphyseal location; descriptive only | [33] | Pak et al. | 2012 | 131 | 5 | Proximal lower extremity | Radiation doseb | [34] | Bishop et al. | 2016 | 596 | 12 | Proximal lower extremity | Univariate competing risk; bone exposure, periosteal stripping, chemotherapy, age Time to fracture analysis: bone exposure, periosteal stripping, chemotherapy | [8] | Folkert et al. | 2019 | 92 | 6 | Thigh and groin | Univariate: age (<60), compartment, periosteal stripping Multivariate: age (<60), periosteal stripping IMRT rate < expected rate for EBRT | [35] |
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