Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma

Table 5

Prognostic factors for overall survival for LA-STS patients. values were calculated using the log-rank test for univariate analysis. For multivariate analysis using a Cox model, only parameters with a in univariate analyses were considered.

Parameter	N	Univariate analysis		Cox model
		Median OS, mo. (95% CI)		HR (95% CI)
Age			0.46
>50 years	38	26 (18–40)
≤50 years	16	23 (10–41)
Sex			0.57
Male	31	28 (13–41)
Female	23	23 (18–93)
Treatment line			0.31
2nd line	46	26 (18–37)
>2nd line	8	20 (10-NA)
Grading			0.12
3	32	23 (16–31)
2	22	31 (28-NA)
Histologic subentity			0.23
Lipo-/leiomyosarcoma	28	29 (13–93)
Non-lipo-/leiomyosarcoma	26	23 (18–37)
Surgery			0.014	0.52 (0.25–1.10)	0.088
Yes	31	18 (8–31)
No	23	28 (23–93)
Response/disease stabilization as the best radiographic response with ICE + RHT			0.039	0.42 (0.18–0.96)	0.041
Yes	26	27 (23–41)
No	9	9 (6–NA)
Type of progression			<0.001	0.69 (0.33–1.45)	0.332
Progression after response to prior chemotherapy	32	31 (23–94)
Primary refractory disease	22	13 (9–31)

HR, hazard ratio; mo., months; NA, not assessable; OS, overall survival.