Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma

Table 2

ICE + RHT treatment characteristics.

	Locally advanced disease (LA-STS, n = 54)	Metastatic disease (M-STS, n = 56)
	Median (range)	Median (range)
ICE cycles	4 (1–8)	4 (1–8)
RHT treatments	8 (2–16)	6 (1–16)
	No. of patients (%)	No. of patients (%)
Radiotherapy	6 (11.1)	6 (10.7)
Surgery	31 (57.4)	15 (26.8)
Surgery prior to start of ICE + RHT	10 (18.5)	1 (1.8)
R0	7 (13.0)	5 (8.8)
R1	10 (18.5)	4 (7.2)
R2	10 (18.5)	4 (7.2)
Rx	4 (7.4)	2 (3.6)
Including metastasectomy		8 (14.3)
Excluding metastasectomy		7 (12.5)

R0, complete resection of the tumor, with no microscopic evidence of tumor infiltration of resection margins; R1, complete macroscopic resection of the tumor, with microscopic evidence of tumor infiltration of resection margins; R2, incomplete resection of the tumor, with macroscopic tumor burden remaining in situ; Rx, resection with unknown resection margins.