Ifosfamide, Carboplatin, and Etoposide (ICE) in Combination with Regional Hyperthermia as Salvage Therapy in Patients with Locally Advanced Nonmetastatic and Metastatic Soft-Tissue Sarcoma
Table 1
Patients’ characteristics and pretreatment. values, representing differences between patients with locally advanced disease and patients with metastatic disease, were assessed by Fisher’s exact test for sex, progression vs. relapse, grading, and pretreatment procedures, by the chi-square test for anatomic site and histopathologic subtype, and by the unpaired t-test for age.
Locally advanced disease
Metastatic disease
(LA-STS, n = 54) No. (%)
(M-STS, n = 56) No. (%)
Age
0.23
Median (range)
56 (18–74) years
51 (21–77) years
<51 years
16 (29.6)
27 (48.2)
>50 years
38 (70.4)
29 (51.8)
Sex
0.26
Male
31 (57.4)
26 (46.4)
Female
23 (42.6)
30 (53.6)
Progression vs. relapse
0.01
Progression of pre-existing lesion(s)
22 (40.7)
37 (66.1)
Relapse after disease-free interval
32 (59.3)
19 (33.9)
Median (range) duration of the disease-free interval
