Time to Treatment Initiation and Survival in Adult Localized High-Grade Bone Sarcoma

Table 3

Univariate relationships between factors and time to treatment initiation.

Factor	N	TTI, days median [p25, p75]	value
Age			0.006
18–30	654	21.0 [13.0, 366.0]
31–50	555	28.0 [14.0, 44.0]
51–70	627	26.0 [12.0, 45.0]
71+	286	25.5 [7.0, 44.0]
Sex			0.52
Male	1241	24.0 [12.0, 42.0]
Female	881	26.0 [13.0, 43.0]
Race			0.050
White	1735	25.0 [12.0, 42.0]
Black	258	28.0 [22.0, 48.0]
Other/unknown	129	20.0 [7.0, 44.0]
Charlson/Deyo score			0.18
0	1843	25.0 [13.0, 42.0]
1	258	22.0 [9.0, 40.0]
≥2	57	29.0[7.0, 44.0]
Histology			0.003
Osteosarcoma	1217	25.0 [13.0, 40.0]
Chondrosarcoma	486	27.0 [10.0, 48.0]
Ewing’s sarcoma	195	21.0 [11.0, 34.0]
Chordoma	17	38.0 [17.0, 77.0]
Other	207	29.0 [15.0, 49.0]
Facility type			<0.001
Comm. cancer prg.	38	32.5 [1.00, 48.0]
Comprehensive comm. cancer Prg.	286	21.5 [5.0, 40.0]
Academic center	856	27.0 [14.0, 47.0]
Integrated network cancer program	62	29.5 [11.0, 52.0]
Other/unknown	880	23.0 [13.0, 37.0]
Insurance			<0.001
Uninsured	120	27.5 [15.0, 43.5]
Private insurance	1148	23.0 [12.0, 39.0]
Medicaid	258	26.0 [13.0, 43.0]
Medicare	454	27.5 [10.0, 48.0]
Other/unknown	142	35.0 [19.0, 52.0]
Income			0.73
<$38,000	404	25.5 [12.0, 45.5]
$38,000–$47,999	500	24.0 [12.0, 40.5]
$48,000–$62,999	563	24.0 [11.0, 43.0]
$63,000+	655	26.0 [14.0, 42.0]
Distance from facility			0.069
>21 miles	974	25.0 [12.0, 42.0]
21–50 miles	466	24.0 [13.0, 42.0]
51–100 miles	306	23.0 [9.0, 40.0]
>100 miles	376	28.0 [14.5, 44.0]
Transition in care			<0.001
No	1137	20.0 [8.0, 35.0]
Yes	985	31.0 [19.0, 49.0]
Year of diagnosis			0.25
2004	160	25.5 [9.0, 42.0]
2005	213	27.0 [14.0, 51.0]
2006	226	24.0 [11.0, 39.0]
2007	202	25.5 [13.0, 43.0]
2008	244	25.0 [13.0, 42.0]
2009	273	23.0 [11.0, 39.0]
2010	274	25.5 [14.0, 41.0]
2011	267	27.0 [14.0, 44.0]
2012	263	25.0 [12.0, 42.0]
Primary tumor site			<0.001
Upper extremity	281	25.0 [14.0, 42.0]
Lower extremity	985	22.0 [12.0, 36.0]
Pelvis	344	29.0 [15.0, 49.0]
Other	512	28.0 [9.5, 48.0]
Tumor size			0.48
≤8.0 cm	967	26.0 [12.0, 42.0]
>8.0 cm	1155	25.0 [13.0, 42.0]
Grade			0.63
Poorly differentiated	1253	25.0 [11.0, 43.0]
Undifferentiated	869	26.0 [14.0, 42.0]
Clinical staging			0.10
Stage I	239	28.0 [14.0, 49.0]
Stage II	1782	24.0 [12.0, 42.0]
Stage III	101	27.0 [11.0, 45.0]
First-line treatment modality			<0.001
Surgery	1029	24.0 [6.0, 47.0]
Radiation	86	34.5 [19.0, 56.0]
Systemic	994	25.0 [15.0, 37.0]
Multimodel	13	39.0 [26.0, 47.0]

values correspond to the Kruskal–Wallis test. Comm.: community; prg.: program; TTI: time to treatment initiation.