The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice

Figure 3

FUS-CHOP-positive primary tumors. pSECC-sgp53 IVE; Rosa26 FUS-CHOP/+ tumors. (a) Gross images of tumors generated via pSECC-sgp53 in vivo electroporation. (b) Tumor growth over time. (c) Tumor-free survival. (d) H&E: IHC with (e) CHOP antibody and (f) CD31 antibody in tumors generated via pSECC-sgp53 in vivo electroporation. (g) Tissue lineage classification of FUS-CHOP-driven sarcomas and Kras^G12D; p53^-/-(KP) murine undifferentiated pleomorphic sarcomas by IHC. Negative control tissues: brain (cytokeratin/desmin/vimentin) and liver (S100). Positive control tissues: liver (cytokeratin), muscle (desmin), brain (S100), and kidney (vimentin).

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