Research Article
The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice
Figure 2
Tumor generation in the adipocytic precursor lineage and immunohistochemical characterization of Prrx1-Cre; Rosa26 FUS-CHOP/+ tumors. (a) Gross image of keratoacanthomas that developed on the skin of the torso, hind limbs, and tails of mice. (b) Gross hind limb sarcomas were observed in mice after spontaneous resolution of keratoacanthomas. (c) Hematoxylin and eosin-stained section of soft tissue sarcoma. (d) FUS-CHOP IHC with CHOP antibody. (e) Section of primary mouse sarcoma from LSL-KrasG12D; p53fl/fl mice stained with CHOP antibody.