SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy
Table 3
Significant cardiac ultrasound findings.
Patient
Ejection fraction at baseline (%)
Ejection fraction range (%)
Notable changes
1
61
57–63
2
59
58–64
C1D1: there was mild eccentric left ventricular hypertrophy. There is mild diastolic dysfunction (impaired relaxation pattern with normal filling pressure) C2D1: there was mild diastolic dysfunction (impaired relaxation pattern with normal filling pressure)
3
66
55–66
4
65
55–65
5
65
60–65
6
64
60–64
C1D12: grade 3 pericardial effusion, pericarditis, and tamponade
7
76
76–81
8
76
67–76
C1D12: mild eccentric left ventricular hypertrophy (increased left ventricular mass with normal relative wall thickness) C2D1: (1) small left ventricular cavity size suggestive of an underfilled left ventricle; (2) there is mild diastolic dysfunction (impaired relaxation pattern with normal filling pressures)
9
55
50–59
10
69
69–73
11
55
55–65
12
68
68–74
13
55
38–55
C3D1: grade 3 reduction in cardiac ejection fraction
