Concurrent Imatinib and Radiation Therapy for Unresectable and Symptomatic Desmoid Tumors
Table 1
Summary of patient characteristics and response to treatment.
Age
Sex
Site
Symptoms
Radiation dose
Radiation toxicity
Imatinib toxicity
Symptom relief (days)
Follow-up (months)
Change in volume
52
M
R back
Pain
50 Gy in 25 fx
Grade 1 fatigue
Grade 2 nausea
7
12
−93%
PR
70
F
L axilla
Pain, weakness, and numbness
54 Gy in 27 fx
Grade 2 fatigue, Grade 1 dermatitis, L breast edema
Grade 2 fatigue, Grade 2 nausea
360
18
−69%
SD
47
F
L axilla
Pain and numbness
50.4 Gy in 28 fx
Grade 2 dermatitis, AVN of L humeral head
Grade 1 nausea
136
3
−8%
SD
63
M
R neck and upper back
Pain
50 Gy in 25 fx
Grade 2 dermatitis
Grade 2 nausea, Grade 2 dysgeusia
42
4
−28%
SD
M = male, F = female, R = right, L = left, and fx = fractions. on change in largest diameter, PR = partial response, SD = stable disease, and AVN = avascular necrosis.