Potential for Modulation of the Fas Apoptotic Pathway by Epidermal Growth Factor in Sarcomas

Table 3

Coexpression matrix for nine Fas-related genes assayed by RT-PCR in 34 SW1353 chondrosarcoma cell cultures treated topically with rhEGF, alone or following EGF/TGFβ receptor inhibition. Correlation coefficients in bold are significant at 𝑃≤1.1𝐸−03 (Bonferroni’s adjustment).

	EGF	TGFβ1	CTGF	Fas	SMAD3	SMAD7	CASP8	CASP10	CFLAR
EGF	1
TGFβ1	0.18	1
CTGF	0.22	0.50	1
Fas	0.28	0.87	0.52	1
SMAD3	0.42	0.47	0.36	0.62	1
SMAD7	0.66	0.23	0.17	0.27	−0.07	1
CASP8	0.76	0.26	0.18	0.38	0.54	0.43	1
CASP10	0.74	0.30	0.13	0.38	0.57	0.34	0.96	1
CFLAR	0.57	0.45	0.12	0.50	0.33	0.56	0.80	0.78	1