Potential for Modulation of the Fas Apoptotic Pathway by Epidermal Growth Factor in Sarcomas

Table 2

Coexpression matrices for nine Fas-related genes assayed by RT-PCR in 23 complete medium control (top panel) and 18 serum-free (SF) control (bottom panel) SW1353 chondrosarcoma cell cultures. Correlation coefficients in bold are significant at 𝑃≤1.1𝐸−03 (Bonferroni’s adjustment).

	EGF	TGFβ1	CTGF	Fas	SMAD3	SMAD7	CASP8	CASP10	CFLAR
EGF	1	0.85	0.73	0.63	0.67	−0.17	0.25	0.19	0.16
TGFβ1	0.26	1	0.91	0.84	0.90	−0.16	0.31	0.18	0.18
CTGF	0.29	0.73	1	0.97	0.95	−0.30	0.10	−0.05	−0.03
Fas	0.36	0.92	0.77	1	0.94	−0.41	−0.07	−0.22	−0.19
SMAD3	0.17	0.84	0.55	0.88	1	−0.20	−0.21	−0.04	−0.01
SMAD7	0.60	0.18	0.35	0.13	−0.07	1	0.60	0.64	0.66
CASP8	0.26	0.03	−0.15	−0.02	0.00	0.51	1	0.95	0.94
CASP10	0.42	0.22	−0.01	0.18	0.10	0.52	0.92	1	0.98
CFLAR	0.21	0.35	0.14	0.23	0.14	0.58	0.86	0.90	1