Radiotherapy for Soft Tissue Sarcoma of the Proximal Lower Extremity

Table 1

Selected outcomes for proximal lower-extremity soft tissue sarcoma.

Author	Date	Number of proximal lower extremity tumors	Treatment type (%)	Median follow up (months)	Local recurrences (%)	Complications (rate)
Enneking et al. [8]; University of Florida	1981	40	Surgery alone	48	6 (15%)	NR
Karakousis et al. [13]; Roswell Park	1998	44	Compartment resection—29 (66%); Wide excision—15 (34%); Radiotherapy—6 (14%)	49	6 (14%)	NR
Yang et al. [4] National Cancer Institute	1998	73	Post-op RT—33 (45%); Surgery alone—40 (55%)	115/118${}^{**}$	6 (13%)/5 (19%)${}^{**}$	NR
Fabrizio et al. [25]; Mayo Clinic	2000	15	Wide local excision (100%)	55	0 (0%)	NR
Vraa et al. [17] Denmark	2001	152	Amputation (18%); Wide local excision (82%); RT (21%)	52	14 (9%)	NR
O'Sullivan et al. [30]; Princess; Margaret Hospital	2002	98	Pre-op RT (45%); Post-op RT (55%)	39	NR	Wound complication: Pre-op—20 (45%); Post-op—15 (28%)
Virkus et al. [34]; University of Florida	2002	130	Pre-op RT	71	10 (11%)${}^{*}$	Wound complication: 41 (26%)${}^{*}$
Rimner et al. [10]; Memorial Sloan Kettering	2009	255	Post-op RT; (BRT alone 63%, EBRT alone 31%, both modalities 6%)	71	24 (9%)	Wound reoperation—24 (9%); Edema—34 (13%); Joint stiffness—32 (13%); Nerve damage—20 (9%); Fracture—15 (6%)

${}^{*}$For all lower-extremity cases (both proximal and distal).
${}^{**}$For high/lowgrade, respectively. NR: not reported; RT: radiotherapy; EBRT: external-beam radiotherapy; BRT: Brachytherapy.