Genetic Profiling Differentiates Second Primary Tumors from Metastases in Adult Metachronous Soft Tissue Sarcoma
Table 1
Summary of clinical data from the 30 STS analyzed from 13 patients.
Case no.
Sex
Age
Site
Type
Years after first tumor
Site
Type
Years after first tumor
Site
Type
Follow-up status/months
Tumor source frozen/paraffin
First tumor
Second tumor
Third tumor
Similar genomic profiles suggestive of metastatic disease
1
M
80
Trunk wall
LMS
3
Left cheek
LMS
MET/50
f/f
2
F
82
Right upper arm
MFH/UPS
2
Left buttock
MFH/UPS
3
Scalp
MFH/UPS
MET/47
p/f/p
6
F
80
Right
thigh
LS
1
Left shoulder
LS
2
Right lower leg†
LS
TD/22
f/p/p
9
F
79
Lower leg
MFH/UPS
1
Right thigh
MFH/UPS
NED/36
p/f
12
M
76
Right lower leg
MFH/UPS
7
Right thigh*
MFH/UPS
TD/164
p/f
Different genomic profiles suggestive of second primary tumors
3
F
77
Right shoulder
MFH/UPS
5
Left thigh
MFH/UPS
9
Right lower arm
LMS
NED/163
f/f
4
F
75
Left lower arm
MFH/UPS
4
Right lower leg
MFH/UPS
NED/54
f/p
5
F
60
Right lower arm
MPNST
4
Right thigh
LMS
NED/56
f/p
7
M
83
Left thigh (laterally)
LMS
4
Left thigh (medially)
LMS
TD/28
p/f
8
M
73
Left knee
MFH/UPS
1
Left lower leg
MFH/UPS
MET/15
f/p
10
M
28
Right trunk wall
MPNST
1
Scalp
MPNST
TD/32
f/p
11
F
77
Right thigh
MFH/UPS
2
Back
MFH/UPS
MET/51
p/f
13
M
76
Right foot
MFH/UPS
4
Right thigh
MFH/UPS
MET/51
p/f
MFH/UPS = malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma,
LMS = leiomyosarcoma, LS = liposarcoma, MPNST = malignant peripheral nerve sheath
tumor.*Located 15 cm from the first tumor.†The patient developed one additional LS, left thoracic wall.MET: metastases, TD: tumor death, NED: no evidence of disease.
