A complicated biological process, aging is characterized by a continuous decline in one's health and physiological functions and is a leading cause of mortality. There are no effective treatments for many of these disorders. Genetic factors such as anomalies in mitochondrial DNA have been linked to a fall in somatic stem cell function and mammalian aging. Alzheimer's disease (AD), diabetes mellitus (DM), cancer, and osteoporosis are the most common age-related disorders. 

A nutrient dense diet with vegetables and fruits containing micronutrients like vitamin C, E, carotenoids, and other phytochemicals that protect against these metabolic diseases has been linked to improved health and longevity. Phytochemicals, which are secondary metabolites made by plants to defend themselves from infections and UV damage, are perhaps the most researched natural chemical. Lignans, stilbenes, phenolic acids, and flavonoids are bioactive chemicals that include aromatic rings with several hydroxyl groups. Numerous phytochemicals have been identified that extend the life span in experimental organisms, implying a clear relationship between polyphenol consumption and longevity. Dietary phytochemicals such as resveratrol, epigallocatechin gallate (EGCG), and luteolin can reduce skeletal muscle stress, decrease inflammation, neutralize reactive oxygen species (ROS), and prevent mitochondrial dysfunction, making them unique anti-aging bioactive substances with a direct life-span-extending impact. Essential nutritional interventional studies have shown that dietary phytochemicals such as EGCG, curcumin, and resveratrol can reduce age-related cellular damage caused by ROS and have other health-promoting benefits in humans.

The aim of this Special Issue is to further investigate these dietary phytochemicals, and the important role they play as anticancer agents capable of inhibiting angiogenesis and metastasis. By regulating the master molecules, they have the potential to govern the biological states of chronic inflammation and oxidative stress. Original research and review articles on this topic are welcome.

Potential topics include but are not limited to the following:

• Antiaging effects of phytomedicines, phytochemicals and other natural products
• Antidiabetic effects of phytomedicines, phytochemicals and other natural products 
• Antiobesity effects of phytomedicines, phytochemicals and other natural products
• Anticancer effects of phytomedicines, phytochemicals and other natural products
• Anti-Alzheimer’s effects of phytomedicines, phytochemicals and other natural products
• Anti-Parkinson’s effects of phytomedicines, phytochemicals and other natural products 
• Therapeutic effects of phytomedicines, phytochemicals and other natural products in osteoporosis
• The mechanisms of actions and the structure-activity relationships (SAR) of each group of compounds