Oxidative Medicine and Cellular Longevity

Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders: The Role of Natural and Synthetic Antioxidants


Publishing date
01 Mar 2019
Status
Published
Submission deadline
19 Oct 2018

1Beni-Suef University, Beni Suef, Egypt

2Manchester Metropolitan University, Manchester, UK

3Detroit R&D Inc., Detroit, USA

4PMAS-Arid Agriculture University, Rawalpindi, Pakistan


Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders: The Role of Natural and Synthetic Antioxidants

Description

Oxidative stress is an imbalance in cellular redox reactions which plays a key role in the pathogenesis of metabolic disorders and drug-induced injury. Oxidative stress is the result of reactive oxygen species (ROS) overproduction or a decline in antioxidant defense mechanisms. Although ROS production can be beneficial in some instances as they are used by the immune system, in general, excessive generation of ROS results in deleterious effects causing damage to DNA, proteins, and lipids, ultimately leading to cell death. Several diseases, including cancer, neurodegeneration, obesity, metabolic syndrome, diabetes mellitus, liver disease, and others, are well-known to be associated with excessive ROS production. Therefore, agents counteracting excess ROS and/or boosting the antioxidant defenses represent an appealing strategy for the treatment of multiple diseases.

Antioxidant substances could be natural or synthetic. Natural antioxidants are obtained entirely from natural sources and have been used in food, cosmetics, and pharmaceutical industries for some time. On the other hand, synthetic antioxidants are substances created from chemical processes. The current understanding of the complex role of ROS in the physiological and pathological processes points to the necessity of developing multifunctional antioxidants, which can maintain oxidative homeostasis, both in health and in disease. In this context, numerous research groups focus on the characterization and application of natural antioxidant agents in different diseases. In addition, a great deal of effort is being conducted to design and synthesize free radical scavenging and antioxidant substances that can diminish excessive ROS production and improve the endogenous antioxidant defenses. Understanding and validating the biological activities of natural and synthetic antioxidant compounds and their molecular mechanisms in counteracting ROS and oxidative stress will provide solid scientific foundation to the application of antioxidants in the prevention and treatment of multiple diseases.

We invite investigators to contribute original research, as well as review articles that illustrate the usefulness of natural and synthetic antioxidants as novel therapeutic approaches to prevent and fight metabolic diseases and drug-induced disorders. The purpose of the special issue will be to focus on articles describing the mechanism underlying the modulatory effect of natural and synthetic antioxidants on oxidative stress.

Potential topics include but are not limited to the following:

  • Role of ROS in metabolic and drug-induced disorders
  • In vitro and in vivo studies on the role of antioxidants in controlling redox imbalance
  • Modulators of the redox-sensitive transcription factors
  • Characterization of the mechanism of action of natural and synthetic antioxidants
  • Natural and synthetic antioxidants as modulators of cellular signaling and metabolism
  • Novel approaches to identify the bioactivity of natural and synthetic antioxidants
  • Therapeutic application of antioxidants in oxidative stress-related diseases

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 3206401
  • - Editorial

Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders: The Role of Natural and Synthetic Antioxidants

Ayman M. Mahmoud | Fiona L. Wilkinson | ... | M. Yvonne Alexander
  • Special Issue
  • - Volume 2019
  • - Article ID 3201873
  • - Research Article

Simvastatin Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in Nonalcoholic Steatohepatitis Experimental Model

Graziella Rodrigues | Andrea Janz Moreira | ... | Norma Possa Marroni
  • Special Issue
  • - Volume 2019
  • - Article ID 6829173
  • - Research Article

In Vitro Anti-Inflammatory Effect of Salvia sagittata Ethanolic Extract on Primary Cultures of Porcine Aortic Endothelial Cells

Irvin Tubon | Augusta Zannoni | ... | Monica Forni
  • Special Issue
  • - Volume 2019
  • - Article ID 1503478
  • - Research Article

Protective Effects of Inorganic and Organic Selenium on Heat Stress in Bovine Mammary Epithelial Cells

Yixuan Zou | Juanjuan Shao | ... | Hongyun Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 3782074
  • - Research Article

ROS Reduction Does Not Decrease the Anticancer Efficacy of X-Ray in Two Breast Cancer Cell Lines

Huizhen Wang | Xin Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 5484138
  • - Review Article

Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Ayman M. Mahmoud | Rene J. Hernández Bautista | ... | Omnia E. Hussein
  • Special Issue
  • - Volume 2019
  • - Article ID 4628962
  • - Research Article

Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs

Ziwei Wang | Junqing Zhang | ... | Xiaohui Guo
  • Special Issue
  • - Volume 2019
  • - Article ID 6290143
  • - Research Article

Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats

May N. Bin-Jumah
  • Special Issue
  • - Volume 2019
  • - Article ID 3457846
  • - Research Article

Indicaxanthin from Opuntia ficus indica (L. Mill) Inhibits Oxidized LDL-Mediated Human Endothelial Cell Dysfunction through Inhibition of NF-κB Activation

Alessandro Attanzio | Anna Frazzitta | ... | Mario Allegra
  • Special Issue
  • - Volume 2019
  • - Article ID 3142732
  • - Research Article

Alphalipoic Acid Prevents Oxidative Stress and Peripheral Neuropathy in Nab-Paclitaxel-Treated Rats through the Nrf2 Signalling Pathway

Hong Sun | Xi Guo | ... | Weimin Cai
Oxidative Medicine and Cellular Longevity
 Journal metrics
Acceptance rate44%
Submission to final decision79 days
Acceptance to publication48 days
CiteScore4.520
Impact Factor4.868
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