Oxidative Stress and Pyroptosis in Doxorubicin-Induced Heart Failure and Atrial Fibrillation

Table 1

Clinical patients’ characteristics.

	Health group ()	Dox baseline ()	Dox-AF after ()	Dox-HF after ()	value
Age					0.823
Gender (M/F)	40 : 44	82 : 92	30 : 32	52 : 60	0.914
Smoking	39 (46%)	85 (49%)	31 (50%)	54 (48%)	0.765
Drinking	12 (14%)	31 (18%)	12 (18%)	19 (17%)	0.862
Hypertension	22 (27%)	50 (29%)	19 (31%)	31 (28%)	0.741
BMI (kg/m)					0.824
TC (mmol/L)					0.713
TG (mmol/L)					0.651
HDL cholesterol (μmol/L)					0.534
LDL cholesterol (μmol/L)					0.658
BUN (mmol/L)					0.382
MDRD-eGFR (mL/min/1.73 m^2)					0.627
b-LDH (IU/L)					0.674
cTnI (ng/mL)	0.17 (0.05, 0.39)	0.18 (0.08, 0.36)	0.21 (0.10, 0.35)	0.25 (0.07, 0.42)	0.876
NT-proBNP (ng/L)					0.008
UCG index
LVEF (%)					0.018
E/A ratio					0.024
LVDd (mm)					0.623
LVFS (%)					0.382
Medicine history
β-Block	6 (7%)	0	47 (76%)	112 (100%)	0
ACEI	8 (9%)	0	12 (19%)	112 (100%)	0
Digoxin	0	0	0	112 (100%)	0
Diuretics	0	0	0	112 (100%)	0

All data were presented as or (%) or median and interquartile range. BMI: body mass index; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; BUN: blood urea nitrogen; MDRD-eGFR: modification of diet in renal disease estimated glomerular filtration rate; b-LDH: blood lactate dehydrogenase; cTnI: cardiac troponin I; NT-proBNP: NT-probrain natriuretic peptide; UCG: ultrasound echocardiogram; LVEF: left ventricular ejection fraction; E/A ratio: ratio of early (E) to late (A) ventricular filling velocities; LVDd: left ventricular end-diastolic diameter; LVFS: left ventricular fractional shortening. value < 0.05 was considered clinical statistically significant.