Metformin Promotes Axon Regeneration after Spinal Cord Injury through Inhibiting Oxidative Stress and Stabilizing Microtubule

Figure 1

Metformin improved functional recovery after SCI. (a) The BBB locomotion scores of the different groups at 1, 3, 5, 7, and 14 days after SCI, per group. (b, c) Quantification of the BBB locomotion scores at 7 and 14 d from (a). ; and vs. the indicated group. (d) Representative images from H&E at 7 dpi. Scale bar: 1000 μm (4x). Scale bar: 200 μm (20x). (e) Quantification data of the percentage of the preserved tissue area from (d). ; and vs. the indicated group. (f) Representative western blots of phosphor-Akt (p-Akt) and total-Akt (t-Akt) in each group. (g) Quantification of western blots data from (f). ; vs. the indicated group.

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