Dioscin Improves Pyroptosis in LPS-Induced Mice Mastitis by Activating AMPK/Nrf2 and Inhibiting the NF-κB Signaling Pathway

Figure 1

Dioscin ameliorates LPS-induced mastitis in mice. (a) Photographs of mammary gland tissue from mice in different treatment groups. (b) HE staining of mammary gland tissue in mice in different treatment groups. The blue arrow represents the accumulation of neutrophils in the acinar cavity, and the black arrow represents thickening of the acinar membrane. The scale bar represents 500 μm. (c) Detection of MPO activity in mammary tissue. (d) Histopathological score of mammary tissue. The mRNA levels of (e) IL-1β，(f) IL-6, and (g) TNF-α in mammary tissue homogenate. The protein levels of (h) IL-1β，(i) IL-6, and (j) TNF-α in mammary tissue homogenate. ^# and ^## compared to the control group; and compared to the LPS group.

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