Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine

Table 4

Inhibitory effect of quercetin on different cancer cells.

Cancer type	Cell lines	Cell cycle	Mechanism
Lymphoma [56]	U937	G2/M	↑ Cyclin B
Osteosarcoma [57]	HOS	G1/S	↓ Cyclin D1
Breast cancer [58]	MCF-7	S	↓ CDK2, cyclins A and B; ↑ p53, p58
Prostate cancer [59]	PC-3, DU-145	G0/G1	↓ Cyclins E and D, PNCA, Cdk-2; ↑ p21, p27