Review Article

Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine

Table 2

Antibiofilm effect of quercetin on bacteria.

Biofilm-producing strainsQuercetin/quercetin conjugateEffect

Bacillus subtilis strain FB17 [41]QuercetinQuercetin diminished biofilm formation

Enterococcus faecalis MTCC 2729 [36]QuercetinAt submic concentrations, quercetin inhibits biofilm formation. Compared with the control group, 10 and 9 proteins were overexpressed and effective after quercetin treatment

A vancomycin-resistant Enterococcus Faecalis [37]Quercetin–pivaloxymethyl conjugate (Q-POM)Q-POM efficiently hampered biofilm formation in a dose-dependent manner

Staphylococcus aureus ATCC 6538 [39]QuercetinQuercetin not only abolished the biofilm forming and hemolytic S. aura but also suppresses the expression of adhesion-related, quorum sensing, and virus-regulatory genes

Staphylococcus aureus ATCC 25923 [39]QuercetinQuercetin not only abolished the biofilm forming and hemolytic S. aura but also suppresses the expression of adhesion-related, quorum sensing, and virus-regulatory genes

A clinical isolate of Staphylococcus aureus [42]Quercetin-AgNP hybridQuercetin-AgNP hybrid significantly reduced the formation of biofilms and the production of extracellular polymers

MSSA ATCC 29213, MRSA ATCC 33591, and clinical isolates of Staphylococcus aureus [43]QuercetinQuercetin (at MIC and sub-MICs) inhibited around 50% of biofilm establishment

Streptococcus mutans strain Ingbritt [44]Quercetin-doped adhesive groupsCompared with the control group, the binder group doped with quercetin showed antibacterial activity, acceptable biocompatibility, inhibition of matrix metalloproteinases, and an effective bonding interfacial seal

Clinical isolates of Pseudomonas Aeruginosa [45]QuercetinQuercetin basically inhibits biofilm formation and twitching movements

Proteus mirabilis HI4320 [46]QuercetinQuercetin dose dependently increased biofilm establishment

Streptococcus pneumoniae strain D39 [47]QuercetinQuercetin reduced biofilm formation and CFUs in a dose-dependent manner