Hyaluronic Acid Improves Hydrogen Peroxide Modulatory Effects on Calcium Channel and Sodium-Potassium Pump in 4T1 Breast Cancer Cell Line

Figure 4

Effect of H₂O₂ or H₂O₂ + HA on the intracellular Ca²⁺ levels in breast cancer cells treated under normoxic or hypoxic conditions after 24 hrs of treatment: (a) (a1) Cells under normoxia and treated with H₂O₂. (a2) Cells under normoxia and treated withH₂O₂ + HA. (a3) Cells under hypoxia and treated with H₂O₂. (a4) Cells under hypoxia and treated with H₂O₂ + HA. Data are shown as () (, , , and vs. respective control). (b) Comparison of intracellular Ca²⁺ levels in 4T1 cancer cells after 24 h of treatments with different concentrations in normoxia and hypoxia conditions determined by scratch assay. Data are shown as () (, , , and vs. similar concentrations in different conditions. Each index is represented with assigned color in the legend).

(a)

(b)