Research Article
Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds
Table 2
Structure, cytotoxicity, and calculated basal toxicity of 3,4-dihydro-2(1H)-pyridones containing cationic moiety.
| Comp. | | Cat+ | | | | HT-1080 | MH-22A | NIH3T3 | Ref. | (CV) (μg/ml) | (MTT) (μg/ml) | (CV) (μg/ml) | (MTT) (μg/ml) | (NR) (μg/ml) | (mg/kg) |
| 28 | H | Py | CH3 | C6H4-OCHF2-2 | Br | | | >100 | | | >2000 | Suppl | 29 | PhCH2 | Py | CH3 | H | Br | | | | | | >2000 | Suppl | 30 | H | PPh3 | (CH2)4(CF2)7CF3 | Ph | Br | | | | | | 1779 | [33] | 31 | H | Py | (CH2)4(CF2)7CF3 | Ph | Br | | | | | | 604 | [33] | 32 | H | Py | (CH2)4(CF2)7CF3 | Ph | ClO4 | | | | | | 618 | Suppl | 33 | H | N-Me2C12H25 | CH3 | Ph | Br | | | | | | 269 | Suppl | 34 | H | N-Me2C12H25 | C12H25 | Ph | Br | | | | | | 346 | Suppl | 35 | H | N-Me2C12H25 | (CH2)4(CF2)7CF3 | Ph | Br | | | | | | 898 | Suppl | 36 | H | N-Me2C12H25 | CH3 | H | Br | | | | | | 831 | Suppl | 37 | H | N-Me2C12H25 | C12H25 | H | Br | | | | | | 369 | Suppl | 38 | H | N-Me2C12H25 | (CH2)4(CF2)7CF3 | H | Br | | | | | | 553 | Suppl |
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