Research Article
Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds
Table 1
Structure, cytotoxicity, and calculated basal toxicity of 1,4-dihydropyridines containing cationic moieties.
| Comp. | Cat+ | | | | | HT-1080 | MH-22A | NIH3T3 | Ref. | (CV) (μg/ml) | (MTT) (μg/ml) | (CV) (μg/ml) | (MTT) (μg/ml) | (NR) (μg/ml) | (mg/kg) |
| 1 | Py | C2H5 | Ph | C2H5 | Br | | | | | | >2000 | [29] | 2 | Py-Me-4 | C2H5 | Ph | C2H5 | Br | | >740 | | | | >3360 | [30] | 3 | Py-NH2-4 | C2H5 | Ph | C2H5 | Br | nt | | nt | >740 | | >3360 | Suppl. | 4 | Py-NMe2-4 | C2H5 | Ph | C2H5 | Br | nt | | nt | | | >3500 | Suppl. | 5 | Py-Me-3 | C2H5 | Ph | C2H5 | Br | nt | >740 | nt | | | >3360 | Suppl. | 6 | Py | C2H5 | C6H4-CF3-2 | C2H5 | Br | | | | | | >2000 | [20] | 7 | Py | C2H4OC3H7 | C6H4-OCHF2-2 | C2H4OC3H7 | Br | | | | | | >2000 | [20] | 8 | Py | C2H5 | COOCH3 | C2H5 | I | | | | | | >2000 | [20] | 9 | N-Me-morph | CH3 | C6H4-OCHF2-2 | CH3 | ClO4 | | | | | | >2000 | [31] | 10 | Py | C12H25 | Ph | C12H25 | Br | | | | | | 1482 | [13, 28] | 11 | Py | C12H25 | Ph | C12H25 | BF4 | | | | | | 1053 | Suppl | 12 | Py-Me-4 | C12H25 | Ph | C12H25 | Br | | | | | | 1431 | [13] | 13 | Py-NMe2-4 | C12H25 | Ph | C12H25 | Br | | | | | | 1706 | [13] | 14 | Py-C(=O)CH3-3 | C12H25 | Ph | C12H25 | Br | | | | | | 4040 | [13] | 15 | N-Me-morph | C12H25 | Ph | C12H25 | ClO4 | | | | | | 979 | [13] | 16 | Pyr | C12H25 | Ph | C12H25 | Br | | | | | | >2000 | [13] | 17 | NMe2CyHex | C12H25 | Ph | C12H25 | Br | | | | | | 1274 | Suppl | 18 | Py | C12H25 | C6H4-OH-4 | C12H25 | Br | | | | | | 1479 | Suppl | 19 | Py-CH3-4 | C12H25 | C6H4-OH-4 | C12H25 | Br | | | | | | 1087 | Suppl | 20 | N-Me2C12H25 | C12H25 | Ph | C12H25 | Br | | | | | | 836 | Suppl | 21 | Py-CF3-4 | C12H25 | Ph | C12H25 | Br | | | | | | 619 | [32] | 22 | Py | C12H24CF3 | Ph | C12H24CF3 | ClO4 | | | | | | 771 | [32] | 23 | Py | C12H25 | Ph | (CH2)4(CF2)7CF3 | Br | | | | | | 3448 | Suppl | 24 | Py | (CH2)4(CF2)7CF3 | Ph | (CH2)4(CF2)7CF3 | Br | | | | | | >2000 | Suppl | 25 | Py | (CH2)11(CF2)7CF3 | Ph | (CH2)11(CF2)7CF3 | Br | | | | | | >2000 | Suppl | 26 | “Dimeric” form of comp. 10 | Br | | | | | | 5164 | Suppl | 27 | Oxidated form of comp. 10 | ClO4 | | | | | | 3946 | [14] |
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nt: not tested; : not detected. |