Inhibition of Mitochondrial ROS by MitoQ Alleviates White Matter Injury and Improves Outcomes after Intracerebral Haemorrhage in Mice

Figure 7

Intracerebral haemorrhage was accompanied demyelination and loss of oligodendrocytes (OLs) and oligodendrocyte precursor cells (OPCs), which resulted in white matter injury. MitoQ treatment reduced OL and OPC death by blocking iron overload-induced mitochondrial damage, which include the increase of mitochondrial ROS and decrease of ATP and mitochondrial membrane potential (). Finally, rescuing white matter injury improved the outcomes after intracerebral haemorrhage.