TNFα Mediates the Interaction of Telomeres and Mitochondria Induced by Hyperglycemia: A Rural Community-Based Cross-Sectional Study

Figure 3

Mediational analysis of antioxidants and inflammatory indicators on the relationship between LTL and mtDNAcn after adjusting for age and gender. (a) a1: the effect of LTL on GR (); b1: the effect of GR on mtDNAcn (); : mediating effect of GR on mtDNAcn; c1: the direct effect of LTL on mtDNAcn after the correction of GR (). (b) a2: the effect of LTL on SOD activity (); b2: the effect of SOD activity on mtDNAcn (); : mediating effect of SOD activity on mtDNAcn; c2: the direct effect of LTL on mtDNAcn after the correction of SOD activity (). (c) a3: the effect of LTL on IL-6 (); b3: the effect of IL-6 on mtDNAcn (); : mediating effect of IL-6 on mtDNAcn; c3: the direct effect of LTL on mtDNAcn after the correction of IL-6 (). (d) a4: the effect of LTL on TNFα (); b4: the effect of TNFα on mtDNAcn (); : mediating effect of TNFα on mtDNAcn; c4: the direct effect of LTL on mtDNAcn after the correction of TNFα ().

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