Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification

Table 1

Spearman correlations (Rho) for SSAO mRNA with mRNA levels of poly(ADP-ribose) polymerase 1 (PARP1), soluble serine hydroxymethyltransferase 1 (SHMT1), NADPH oxidase 4 (NOX4), cytochrome b-245, alpha polypeptide (CYBA), and superoxide dismutases (SOD) 1-3 in healthy, intermediate, and calcified tissue from human aortic valves. Bonferroni-corrected significance threshold is 0.007.

Healthy	PARP1	SHMT1	NOX4	CYBA	SOD1	SOD2	SOD3
Rho	0.045	0.32	-0.059	0.052	-0.11	0.28	0.33
	0.722	0.011	0.642	0.682	0.399	0.027	0.0075
	64	64	64	64	64	64	64
Intermediate	PARP1	SHMT1	NOX4	CYBA	SOD1	SOD2	SOD3
Rho	0.26	0.27	0.20	0.41	0.042	0.26	0.34
	0.036	0.031	0.12	0.00096	0.74	0.043	0.0064
	64	64	64	64	64	64	64
Calcified	PARP1	SHMT1	NOX4	CYBA	SOD1	SOD2	SOD3
Rho	0.37	-0.17	-0.075	0.21	-0.21	0.055	-0.11
	0.0031	0.18	0.56	0.099	0.093	0.67	0.38
	64	64	64	64	64	64	64