Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model

Figure 8

Cell viability decreases and lipid peroxidation and cleaved caspase-3 rise after LPS and MPTP challenges. Mice were administered with saline solution, mLPS (100 μg/kg twice a week for three months), sLPS (5 mg/kg), and MPTP (30 mg/kg for five consecutive days). Cell viability assessed by MTT reduction (a, b), cleaved caspase-3 (c, d), and lipid peroxidation determined by TBARS method (e, f) were determined in the substantia nigra (a, c, e) and striatum (b, d, f). Data represent () and were analyzed by two-way ANOVA, followed by a Tukey’s post hoc test. Different letters indicate significant differences among the experimental groups ().