Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model

Figure 5

Iba1 staining increases in the substantia nigra after LPS administration and MPTP challenge. Representative images showing Iba1 immunodetection in grayscale in the substantia nigra of mice administered with saline solution, mLPS (100 μg/kg twice a week for three months), sLPS (5 mg/kg), and MPTP (30 mg/kg for five consecutive days) (a). Quantification of the fluorescence intensity of Iba1 staining in the substantia nigra from the different experimental groups (b). Data represent () and were analyzed by two-way ANOVA, followed by a Tukey’s post hoc test. Different letters indicate significant differences among the experimental groups ().

(a)

(b)