4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action

<div>The effect of L-type calcium ion channel antagonists on evoked by compound Ca<sup>2+</sup> ion channel activity. (a) The effect of amlodipine on evoked by compound 4 Ca<sup>2+</sup> ion channel activity. (b) The effect of nifedipine on evoked by compound 4 Ca<sup>2+</sup> ion channel activity. Fura-4 NW loaded SH-SY5Y cells were preincubated with amlodipine and nifedipine in the 100 <i>μ</i>M concentration for 15 min, and thereafter, the cells were stimulated (arrow) by the addition of compound 4 (concentration 100 <i>μ</i>M). Control is Fura-4 NW loaded cells without stimulator. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: 4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action 