4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action

<div>The dose-dependent calcium ion channel agonist activity. (a) [Ca<sup>2+</sup>]<sub>i</sub> responses to different concentrations of agonist compound 4 in SH-SY5Y cells. (b) [Ca<sup>2+</sup>]<sub>i</sub> responses to different concentrations of agonist Вау K8644 in SH-SY5Y cells. (c) [Ca<sup>2+</sup>]<sub>i</sub> responses to different concentrations of agonist compound 4 in A7R5 cells. The cells were stimulated by the addition of compound 4 or Bay K8644 in concentration range from 20 to 100 <i>μ</i>M. Control is Fura-4 NW loaded cells without stimulator. Arrow indicates the time of compound 4 and Bay K8644 addition. 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: 4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action 