Research Article
NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway
Figure 6
NAMPT reduces intracellular ROS levels through SIRT1 signaling in vivo and in vitro. DHE fluorescent probes and DCFH-DA were used to detect the level of ROS in MAECs (a) and MOVAs (b) with Sirt1 silencing, NAMPT overexpression, and Ang II stimulation. DHE (red) and DCF-DA (green). Scale μm. (c) DHE staining of fresh aortic wall tissues from NAMPT+/- and WT stimulated with Ang II ( in each group). DHE (red). Scale μm. Data are presented as . and compared with the corresponding saline group or between the 2 indicated groups.
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