NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway

Figure 2

NAMPT haplodeficiency exacerbates changes in blood pressure and promotes the expression of remodeling-related molecules after Ang II stimulation. (a) The levels of the NAMPT mRNA and protein in the aortic wall tissues obtained from WT and NAMPT+/- mice treated with saline or Ang II ( in each group). (b) Representative images of H&E staining showing the remodeling of arteries (scale  μm, in each group, ≥40 fields per group). (c) M, L, and their ratio in the aorta. (d) The SBP, MAP, DBP, and HR were measured with a noninvasive computerized tail-cuff system in conscious mice. (e) Relative mRNA levels of CTGF, collagen I, and collagen III and the ratio of collagen type I and type III in WT littermates and NAMPT+/- mice treated with saline or Ang II treatment ( animals per group), as well as the picrosirius red staining (PSR). Data are presented as . and compared with the corresponding saline group; NS: not significant.

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