NAMPT/SIRT1 Attenuate Ang II-Induced Vascular Remodeling and Vulnerability to Hypertension by Inhibiting the ROS/MAPK Pathway

Figure 1

NAMPT expression is reduced in tissues from patients with hypertension and MOVAs and MAECs exposed to Ang II. (a) Immunohistochemical staining for NAMPT in tissues from patients with hypertension and control patients (scale  μm) and quantification of NAMPT-positive cells ( in each group, ≥40 fields per group). Data are presented as . compared with the group. (b) Immunohistochemical staining for NAMPT in tissues from the Ang II-infused rats and sham rats (scale  μm) and quantification of NAMPT-positive cells ( in each group, ≥40 fields per group). Data are presented as . compared with the group. (c) Representative Western blots and quantification showing NAMPT levels in the patients with hypertension and control patients (in each group). (d) Representative Western blots and quantification showing NAMPT levels in the Ang II-infused rats and sham rats ( in each group). Representative Western blots and quantification showing NAMPT levels in MAECs (e) and MOVAs (f) after Ang II stimulation for 48 hours. Data are presented as and compared with the sham or PBS groups.

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