Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism

Figure 1

PRDX6^-/- mice on a HFD exhibit a different metabolic response compared to WT mice. (a and b) Body weight curves of age-matched WT (open circle, solid line) and PRDX6^-/- mice (filled triangle, dashed line) fed with SCD (a) and HFD (b) for 24 weeks ( mice per group). Measurements of food (c and d) and drink (e and f) intake obtained using metabolic cages in WT (black bar) and PRDX6^-/- mice (white bar) fed with SCD (c and e) and HFD (d and f) ( mice per group). (g and h) Horizontal and vertical movement of WT (open circle, solid line) and PRDX6^-/- mice (filled triangle, dashed line) fed with SCD (g) and HFD (h) for 24 weeks ( mice per group). (i) Measurement of gas exchange (VO₂ and VCO₂) and RER (VCO₂/VO₂) in WT (black bar) and PRDX6^-/- mice (white bar) fed with SCD ( mice per group). (j) VO₂, VCO₂, and RER calculation in WT (black bar) and PRDX6^-/- mice (white bar) after 24 weeks on HFD ( mice per group). The results are . Statistically significant differences between PRDX6^-/- mice and WT mice are indicated; , , , and .

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