SIRT1 Modulators in Experimentally Induced Liver Injury

Table 1

Effects of quercetin and SRT1720 pretreatments in lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized (D-GalN/LPS) rats on the levels of AST, ALT, and catalase in plasma and conjugated dienes in liver homogenate, after 24 hours.

	ALT (IU/l)	AST (IU/l)	AST : ALT ratio	Catalase (nmol/l)	Conjugated dienes (nmol/mg protein)
CO
Q
SRT1720
D-GalN/LPS
-GalN/LPS
-GalN/LPS

CO: negative control, vehicle only; Q: quercetin 50 mg/kg; SRT1720: SRT1720 5 mg/kg; D-GalN/LPS: D-galactosamine 10 μg/kg; -GalN/LPS: combination of Q and D-GalN/LPS; -GalN/LPS: combination of SRT1720 and D-GalN/LPS. indicates significant values () compared to the negative control group (vehicle only); indicates significant values () compared to the D-GalN/LPS group. The results are expressed as , -8. Included as an endogenous antioxidant (courtesy of Physiological Research, reference [98]).