SIRT1 Modulators in Experimentally Induced Liver Injury

Figure 2

Effects of quercetin and SRT1720 pretreatments on (a) SIRT1 and (b) HO-1 protein expressions in lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized (D-GalN/LPS) rats after 24 hours. Beta-actin was used as an endogenous control. CO: negative control, vehicle only; Q: quercetin 50 mg/kg; SRT1720: SRT1720 5 mg/kg; D-GalN/LPS: D-galactosamine 10 μg/kg; -GalN/LPS: combination of Q and D-GalN/LPS; -GalN/LPS: combination of SRT1720 and D-GalN/LPS. indicates significant values () compared to the negative control group (vehicle only); indicates significant values () compared to the D-GalN/LPS group. The results are expressed as , (courtesy of Physiological Research, reference [98]).

(a) SIRT1 expression

(b) HO-1 expression