Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications

Figure 1

(a) Chemical structure of DCA. (b) Mechanism of action of DCA: PDK: pyruvate dehydrogenase kinase; PDH: pyruvate dehydrogenase. Black dotted lines, biochemical processes inhibited by DCA; Red arrows, metabolic pathways activated by DCA.

(a)

(b)