Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression

Figure 4

C33 dose-dependently inhibits cytokine production in DSS-induced colitis mice. WT mice were treated with C33 (10–400 mg/kg i.g.) or vehicle (10% ethanol) daily. Two days later, while the mice continued with the daily C33 treatment, they were also given normal drinking water or water containing 2.5% DSS for 7 days. At the end of experiments, blood was taken. Levels of IL-6 and TNF-α in plasma were measured by ELISA. Values are (). , the asterisks indicate a significant difference compared to the vehicle group.

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