Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

Figure 2

Crosstalk between oxidative stress and inflammation. Interaction between ROS and mediators of inflammation exemplified by redox regulation of the transcription factors Nrf2 and NF-κB and the NLRP3 inflammasome as well as their downstream targets. In several pathways, inhibitory effects by antioxidants or genetic deletion of ROS sources are indicated. Modified from Wenzel et al. [100] (with permission from Elsevier. © 2017 Elsevier Inc.; all rights reserved).