The Ameliorative Effects of the Ethyl Acetate Extract of Salicornia europaea L. and Its Bioactive Candidate, Irilin B, on LPS-Induced Microglial Inflammation and MPTP-Intoxicated PD-Like Mouse Model

Figure 4

SE-EA-attenuated motor deficits and tyrosine hydroxylase depletion in MPTP-intoxicated PD-like mouse model. Animal experiment schedule is presented (a). Mouse coordination function was measured using a pole test. Each result is marked by dots and a thick bar is (b). In IHC/DAB, the staining results indicate TH-positive neurons (substantia nigra pars compacta or SNpc) and its axon terminals (striatum or Str.). In the SNpc region, dopaminergic neurons stained by the IHC/DAB staining method and the TH-positive area were measured using ImageJ (c). In the graph, the relative TH-positive area’s is presented (d). ^### vs. the control group and , , and vs. LPS-stimulated group. values were achieved using a one-way ANOVA analysis (Tukey method).

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