Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro

Figure 8

Inhibitory impacts of PCr on MGO-actuated H9C2 ROS overproduction. (a) Cells were treated with convergences of (5~20 mM) PCr or 2 mM NAC for 2 h before being animated with (1 mM) MGO for 24 h. (b) Quantification ROS age. (c) Protective impacts of PCr against MGO-initiated mitochondrial brokenness in H9C2 cells. The impact of PCr on mitochondrial membrane potential. The Δψm in each group was computed as the proportion of red to green fluorescence. (d) Data are presented as the (). vs. the control group. , , and vs. the MGO group.

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