Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro

Figure 5

Protective impacts of PCr against MGO-actuated damage and apoptosis in H9C2 cells. (a) Chemical structure of phosphocreatine. (b) Effect of pretreatment with PCr (5~20 mM) for 2 h, on the cell morphology and structure of H9C2 cells by bright image (100x magnification) examination. (c) The apoptosis occurrences of H9C2 were stained by DAPI observed by fluorescence images for (200x final magnification). (d) MGO-induced toxicity (0.2~1.2 mM) on H9C2 cell. (e) Effect of PCr (5~20 mM) on induced MGO H9C2. (f) Cytotoxicity of PCr on H9C2 cells. The effects of PCr on the loss of cell practicality, initiated by MGO. Data are displayed as the (). vs. the control group. and vs. the MGO group.

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