DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling

Figure 2

Sitagliptin attenuates SAP-induced intestine injury in mice. Mice received sitagliptin (100 or 200 mg/kg, IP) or vehicle 1 h prior to cerulein+ LPS (SAP model). The serum, pancreas, and intestine tissues were then harvested 24 h after the last intraperitoneal injection. (a) DPP4 activity in serum. (b) The cytokines’ IL-6 in serum. (c) The cytokines’ IL-1β in serum. (d) Representative hematoxylin and eosin- (H&E-) stained pancreas and intestine sections (×200). (e) The pancreatitis score. (f) Histological scores to evaluate the degree of injury. Slides were evaluated by two independent investigators in a blinded manner. Data are presented as error of the mean (SEM) (). , compared with the N group. p < 0.05, compared with the SAP group. N, the control group; SAP, the severe acute pancreatitis group; SAP+SIT 100, the severe acute pancreatitis+100 μM sitagliptin group; SAP+SIT 200, the severe acute pancreatitis+200 μM sitagliptin group.

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