IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice

Table 1

Profiling hematopoietic stem/progenitor cells in bone marrow and splenic cells.

Bone marrow cells	Days	0 Gy	5 Gy	5 Gy+IMD-0354
		Cell counts (×10^6 cells)
Population enriched with hematopoietic stem/progenitor cells	Day 7
	Day 30	ND		^b
Multipotent progenitor	Day 7
	Day 30	ND	0.11 ± 0.01	0.17 ± 0.01^b
Common myeloid-erythroid progenitor	Day 7
	Day 30	ND
Common lymphoid progenitor	Day 7
	Day 30	ND
Splenic cells	Days	0 Gy	5 Gy	5 Gy+IMD-0354
Population enriched with hematopoietic stem/progenitor cells	Day 7
	Day 30	ND	0.13 ± 0.05	0.33 ± 0.08^a
Multipotent progenitor	Day 7
	Day 30	ND
Common myeloid-erythroid progenitor	Day 7
	Day 30	ND
Common lymphoid progenitor	Day 7
	Day 30	ND

Each cell population was classified according to the following surface antigens. Population enriched with hematopoietic stem/progenitor cells: Lin^– c-kit⁺ Sca-1⁺ CD34^–; multipotent progenitor: Lin^– c-kit⁺ Sca-1⁺ CD34⁺; common myeloid-erythroid progenitor: Lin^– c-kit⁺ Sca-1^– CD34⁺; common lymphoid progenitor: Lin^– c-kit^– Sca-1⁺ CD34⁺. The data are expressed as the , and statistical significance was determined by a comparison of each group (^avs. 5 Gy cohort; ^bvs. 5 Gy cohort). ND: no data.