Dose-Dependent Behavioral and Antioxidant Effects of Quercetin and Methanolic and Acetonic Extracts from Heterotheca inuloides on Several Rat Tissues following Kainic Acid-Induced Status Epilepticus

Table 3

Effects of extracts of H. inuloides and quercetin on carbonylated proteins in the cerebellum, prefrontal cortex, cerebral hemispheres, and medulla of Wistar rats untreated or treated with kainic acid (KA).

Treatment	Untreated (nM/mg prot)	Treated (KA) (nM/mg prot)	Untreated (nM/mg prot)	Treated (KA) (nM/mg prot)	Untreated (nM/mg prot)	Treated (KA) (nM/mg prot)	Untreated (nM/mg prot)	Treated (KA) (nM/mg prot)
Tissue	Cerebellum		Prefrontal cortex		Cerebral hemispheres		Medulla
Control 30
Control 100
Control 300
Phosphate buffer
30 mg/kg
100 mg/kg
300 mg/kg
Olive oil
30 mg/kg
100 mg/kg
300 mg/kg
Methanolic extract
30 mg/kg
100 mg/kg
300 mg/kg
Acetonic extract
30 mg/kg
100 mg/kg
300 mg/kg
Quercetin
30 mg/kg
100 mg/kg
300 mg/kg

The effect of KA on the cerebellum, prefrontal cortex, cerebral hemispheres, and medulla was observed among all groups. Its effect was significantly different in all groups (cerebellum: , ; prefrontal cortex: , ; cerebral hemispheres: , ; and medulla: , ). Each quantification was performed in triplicate on samples from six rats, and the values represent the . Differences were analyzed using one-way analysis of variance (ANOVA) followed by the Bonferroni test.