Pioglitazone Protects Compression-Mediated Apoptosis in Nucleus Pulposus Mesenchymal Stem Cells by Suppressing Oxidative Stress

<div>Effect of pioglitazone on compression-induced mitochondrion damage in NP-MSCs. (a) JC-1 staining was used to detect MMP in NP-MSCs by flow cytometric analysis. (b) Quantitative analysis of MMP in NP-MSCs. (c) MMP of NP-MSCs was observed under a fluorescence microscope (200x). (d) The cell nucleus and mitochondria of NP-MSCs were observed by TEM in three groups. Mitochondria were displayed as indicated by the arrowheads (1700x and 5000x). (e) Quantitative analysis of mitochondrion numbers in NP-MSCs. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Pioglitazone Protects Compression-Mediated Apoptosis in Nucleus Pulposus Mesenchymal Stem Cells by Suppressing Oxidative Stress 