Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs

Figure 1

Alterations in aorta histopathology and NO concentrations in the four groups. (a) Representative images of HE staining in sections of the rat aorta, magnification 400x. (b) Representative images of Verhoeff-Van Gieson staining in sections of the rat aorta, magnification 400x. The scale bar indicates 20 μm. (c) Serum NO metabolite levels after 12 weeks of treatment. . (d) NO metabolite levels in the rat aorta after 12 weeks of treatment. . (e) The aortic intima-media thickness after 12 weeks of treatment. -8. Control: healthy rats receiving normal tap water. CG: healthy rats receiving water containing 1% (/) glycine. DM: diabetic rats receiving normal tap water. DG: diabetic rats receiving water containing 1% (/) glycine. , compared with the control group; compared with the DM group.

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